Genetically modified golden rice meets Bangladesh's safety standard
The totality of the assessment that provides assurance that GR2E is as safe as conventional rice
Golden Rice, a genetically modified (GM) crop, has met food safety standards set by Bangladesh, Philippines, and Indonesia, says an assessment.
Completion of the food safety assessment is a required prerequisite to conduct the bioefficacy studies with GR2E, which are an important component in demonstrating the value of GR2E rice in mitigating Vitamin A deficiency (VAD), according to Genetic Literacy Project.
The totality of the assessment that provides assurance that GR2E is as safe as conventional rice involves characterisation of introduced genes and proteins.
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Vitamin A deficiency persists as a major public health nutrition problem, especially in sub-Saharan Africa and South Asia. Severe deficiency can lead to disorders such as xerophthalmia, the leading cause of preventable childhood blindness, anemia, and weakened host resistance to infection, which can increase the severity of infectious diseases and risk of death.
The GR2E rice was developed through the use of recombinant-DNA techniques to express elevated levels of provitamin A (mainly ß-carotene) in the endosperm, which is converted in the body to vitamin A.
The molecular-genetic characterization of GR2E rice, including the assessment of potential toxic or allergic reaction to the newly expressed ZmPSY1 and CRTI proteins, when considered together with the comparative compositional assessment, support the conclusion that food derived from rice varieties containing event GR2E is as safe as food derived from conventional rice varieties.
All the data presented in the regulatory dossier is mainly intended to meet the regulatory requirements in Philippines, Bangladesh, and Indonesia.
