Guitarist Steve Hackett will also miss the shows.
British rock band Genesis have reformed to perform on a tour after a 13 year hiatus. Phil Collins, Mike Rutherford and Tony Banks- members of the band confirmed on a BBC radio 2 show on Wednesday.
"I think it's a natural moment," said Banks. "We're all good friends, we're all above grass and... here we are."
The progressive rock pioneer will play live shows in Liverpool, Leeds, Belfast, Manchester, Newcastle and Glasgow as well as two nights at London's O2 Arena.
Founding member Peter Gabriel left the group in 1975. He won't be joining the tour. Guitarist Steve Hackett will also miss the shows.
Collins, whose voice was croaky after a recent illness, said the set list was still coming together.
Rumours they may reunite had been circulating for a while after Collins and Rutherford performed together in Berlin last June. Collins, originally the drummer for the band before became lead singer after Gabriel exited. He is unlikely to be drumming on this latest tour.
Collins has previously revealed he suffered nerve damage to his hands which meant he would "never play the way I used to". His son Nicholas played drums for him on his solo 'Not Dead Yet' Tour in 2017.
The band was founded at Charterhouse School in Surrey in 1967. They have achieved international success recording 15 studio albums. They have sold at least 100 million records worldwide.
Tickets for the shows will go on sale at 10.00am on Friday.