The US dollar, meanwhile, was marginally lower against the Antipodean currencies and oil prices crept higher
Asia's stock markets opened higher on Monday, as vaccine optimism offset worries about rising coronavirus cases in Europe and new lockdowns in the United States, while oil prices and risk-exposed currencies also edged higher.
Japan's Nikkei .N225 opened 1% higher at 29-year peak. Australia's ASX 200 .AXJO rose 1% to an eight-month high and MSCI's broadest index of Asia-Pacific shares outside Japan .MIAPJ0000PUS stood at its highest since January 2018.
S&P 500 futures ESc1 rose 0.7% following the index's record closing high on Friday and futures pointed to positive a positive start to the week in Hong Kong HSIc1.
The US dollar, meanwhile, was marginally lower against the Antipodean currencies. Oil prices crept higher, though not enough to recoup late-week losses on worries about the winter ahead.
Traders are expecting more good vaccine news as soon as this week from drugmaker Moderna MRNA.O, following the successful trial of Pfizer's PFE.N similar drug - and that seems enough to assuage nearer-term concerns about the virus' economic harm.
"There's just mountains of cash sitting on the sidelines, waiting to be put to work and since we've got this vaccine news, as well as diminished risk around the US elections, all of this is flying into equities," said Kyle Rodda, analyst at IG Markets. "Everyone's thinking now that it's the cue to get in."
President Donald Trump appeared on Sunday to acknowledge losing the US election but then backtracked and said he concedes "nothing," while President-elect Joe Biden focused on tackling the coronavirus pandemic.
In North Asia, Japan's quarterly economic growth beat expectations while China's factory output and retail trade data is due later in the day.
Fifteen Asia-Pacific economies, including China and Japan but excluding the United States agreed to a trade deal over the weekend which, although light on detail or immediate tariff cuts, is a landmark pact for East Asian exporters.
"(The) agreement ... signals that Asia keeps pushing ahead with trade liberalisation even as other regions have become more sceptical," said HSBC economists Frederic Neumann and Shanella Rajanayagam in a note.
"As such, it may reinforce a trend that's been already underway for decades: that the global centre of economic gravity keeps pushing relentlessly to the East."
Brexit Crunch Looms, Again
In currency markets, majors were mostly flat apart from sterling, which made a nervous start to a week that looms large for Brexit trade talks, slipping a tad against the euro EURGBP= and the dollar GBP= to last hold at $1.3180.
The departure of hardline adviser Dominic Cummings from Downing Street last week may leave more room for British compromises, but chief negotiator David Frost said on Twitter that talks "may not succeed".
Negotiations have already missed several deadlines and the next one looms with Thursday's European Union summit.
The euro EUR= brushed a one-week high of $1.1845 in early Asia trade and the yen JPY= sat at 104.66 per dollar.
The risk-sensitive Australian dollar AUD=D3 bought $0.7284 and was steady ahead of a week of central bank speeches and significant data, beginning with Reserve Bank of Australia Governor Philip Lowe at 0840 GMT.
A slew of US Federal Reserve speakers are also up this week, beginning with Vice Chair Richard Clarida at 1900 GMT.
Bonds, which had sold off strongly on vaccine news last week, pared some losses into Friday's New York close to leave the yield on benchmark US 10-year debt US10YT=RR at 0.8930%, from a week high above 0.97%.
Oil prices inched higher, with Brent crude futures LCOc1 up 0.4% to $42.94 a barrel but below last week's two-month high of $45.30. US crude CLc1 rose 0.6% to $40.37 a barrel.
Gold XAU= held steady at $1,890 an ounce.